Won

1993
• ShoWest Convention: Male Star of Tomorrow

1995
• MTV Movie Awards: Best Male Performance (Interview with the Vampire)
• Razzie Awards: Worst Screen Couple (Interview with the Vampire)
• Western Heritage Awards: Bronze Wrangler: Theatrical Motion Picture (Legends of the Fall)

1996
• Academy of Science Fiction, Fantasy & Horror Films: Best Supporting Actor (12 Monkeys)
• Golden Globes: Best Supporting Actor (12 Monkeys)
• MTV Movie Awards: Most Desirable Male (Se7en)
• Sci-Fi Universe Magazine: Best Supporting Actor (12 Monkeys)

1997
• Blockbuster Entertainment Awards: Favorite Supporting Actor – Science Fiction (12 Monkeys)

1998
• Rembrandt Awards: Best Actor (Seven Years in Tibet)

2004
• Teen Choice Awards: Choice Movie Actor (Troy)

2005
• MTV Movie Awards: Favorite Leading Man
• Teen Choice Awards: Choice Movie Rumble (Mr & Mrs Smith)

2006
• Gotham Awards: Best Ensemble Cast (Babel)
• MTV Movie Awards: Best Fight (Mr & Mrs Smith)
• People’s Choice Awards: Favorite Leading Man

2007
• Palm Springs International Film Festival: Ensemble Performance Award (Babel)
• Venice Film Festival: Volpi Cup: Best Actor (The Assassination of Jesse James)

2008
• People’s Choice Award: Favorite On Screen Match-up (Ocean’s 13)

2009
• People’s Choice Award: Favorite Leading Man

2010
• Central Ohio Film Critics Association: Best Ensemble (Inglourious Bastards)
• Screen Actors Guild Awards: Outstanding Performance by a Cast in a Motion Picture (Inglourious Bastards)

Nominated

1995
• Academy of Science Fiction, Fantasy & Horror Films: Best Actor (Interview with the Vampire)
• Golden Globes: Best Performance by an Actor in a Motion Picture (Legends of the Fall)
• MTV Movie Awards: Best On-Screen Duo (Interview with the Vampire)

1996
• Academy Awards: Best Supporting Actor (12 Monkeys)
• MTV Movie Awards: Best Male Performance (12 Monkeys)
• MTV Movie Awards: Best On-Screen Duo (Se7en)

2000
• Blockbuster Entertainment Awards: Favorite Action Team (Fight Club)

2001
• Satellite Awards: Best Supporting Actor (Snatch)
• Teen Choice Awards: Choice Movie Chemistry (The Mexican)

2002
• Emmy Awards: Outstanding Guest Actor in a Comedy Series (Friends)
• MTV Movie Awards: Best On-Screen Team (Ocean’s 11)
• Phoenix Film Critics Society Awards: Best Acting Ensemble (Ocean’s 11)
• Teen Choice Awards: Choice Movie Actor (Ocean’s 11)

2003
• DVD Exclusive Awards: Best Audio Commentary (Ocean’s 11)

2004
• Kids’ Choice Awards: Favorite Voice from an Animated Movie (Sinbad)
• Total Request Live Awards: Biggest Star Who Promises To Appear But Never Does Award

2005
• Critics Choice Award: Best Acting Ensemble (Ocean’s 12)
• Irish Film and Television Awards: Best Int. Actor (Mr & Mrs Smith)
• MTV Movie Awards: Best Fight (Troy)
• MTV Movie Awards: Best Male Performance (Troy)
• Teen Choice Awards: Choice Movie Actor (Mr & Mrs Smith)
• Teen Choice Awards: Choice Movie Chemistry (Mr & Mrs Smith)
• Teen Choice Awards: Choice Movie Dance Scene (Mr & Mrs Smith)
• Teen Choice Awards: Choice Movie Liar (Mr & Mrs Smith)
• Teen Choice Awards: Choice Movie Liplock (Mr & Mrs Smith)

2006
• Chicago Film Critics Association Awards: Best Supporting Actor (Babel)
• MTV Movie Awards: Best Kiss (Mr & Mrs Smith)
• People’s Choice Awards: Favorite Male Action Star (Mr & Mrs Smith)
• People’s Choice Awards: Favorite On-Screen Match-Up (Mr & Mrs Smith)
• Satellite Awards: Best Actor in a Supporting Role (Babel)

2007
• BAFTA Awards: Best Film (Plan B: The Departed)
• Golden Globes: Best Supporting Actor (Babel)
• People’s Choice Awards: Favorite Leading Man
• Screen Actor’s Guild Awards: Outstanding Cast(Babel)
• Teen Choice Awards: Choice Movie: Chemistry (Ocean’s 13)

2008
• Independent Spirit Awards: Best Feature (Plan B: A Mighty Heart)

2009
• Academy Awards: Best Actor (Benjamin Button)
• BAFTA Awards: Best Actor (Benjamin Button)
• BAFTA Awards: Best Supporting Actor (Burn After Reading)
• Critics Choice Awards: Best Acting Ensemble (Benjamin Button)
• Critics Choice Awards: Best Actor (Benjamin Button)
• Golden Globes: Best Actor (Benjamin Button)
• Screen Actors Guild Awards: Best Actor (Benjamin Button)
• Screen Actors Guild Awards: Outstanding Cast (Benjamin Button)
• Saturn Award: Best Actor (Benjamin Button)
• Teen Choice Awards: Choice Movie Actor: Drama (Benjamin Button)

2010
• People’s Choice Awards: Favorite Movie Actor